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林惠菁
林惠菁
專任教授
02-2826-7944
hclin7picym.edu.tw;hclin7picnycu.edu.tw
動物行為、電生理學、神經訊息傳遞


學歷
  • 學歷
  • 經歷
  • 代表著作
  • 五年內執行計畫
  • 實驗室成員
  • 實驗室活動
  • 研究方向
年度 學校名稱 學位
1998 台北醫學大學藥學系 藥學士
2000 國立成功大學藥理所 碩士
2008 國立成功大學基礎醫學所 博士
年度 服務機關名稱 單位 職務
2019- 國立陽明大學 生理學科暨生理學研究所 教授
2016-2019 國立陽明大學 生理學科暨生理學研究所 副教授
2011-2016 國立陽明大學 生理學科暨生理學研究所 助理教授
2008-2011 國立成功大學 藥理所 博士後研究員
2011 法國馬賽國家衛生暨醫學研究院 訪問博士後研究員
2010 美國德州貝勒醫學中心 小兒研究部門 訪問博士後研究員
2000-2003 基隆長庚 藥劑部 藥師
排序編號 著作名稱
1

Lee CW, Wu HF, Chu MC, Chung YJ, Li CT*, Lin HC* Mechanism of intermittent theta-burst stimulation in synaptic pathology in the prefrontal cortex in an antidepressant-resistant depression rat model. Cerebral Cortex. 2020 (in press) *co-corresponding author.

2

Chu MC, Lee JY, Lee HF, Chu KW, Wu HF, Lee CW, Lin CH, Tang CW*, Lin HC*. Increased GABAergic inhibitory function against ischemic long-term potentiation in the CA1 region of the hippocampus. Biochem Biophys Res Commun. 2020 Mar 29. pii: S0006-291X(20)30601-X. *co-corresponding author.

3

Wu HF, Lu TY, Chu MC, Chen PS, Lee CW, Lin HC*. Targeting the inhibition of fatty acid amide hydrolase ameliorate the endocannabinoid-mediated synaptic dysfunction in a valproic acid-induced rat model of Autism. Neuropharmacology. 2020 Jan 162:107736

4

Chang CW, Lo YC, Lin SH, Yang SH, Lin HC, Lin TC, Li SJ, Hsieh CC, Ro V, Chung YJ, Chang YC, Lee CW, Kuo CH, Chen SY, Chen YY. Modulation of Theta-Band Local Field Potential Oscillations Across Brain Networks With Central Thalamic Deep Brain Stimulation to Enhance Spatial Working Memory. Front Neurosci. 2019 Nov 26;13:1269

5

Lin TC#, Lo YC#, Lin HC#, Li SJ, Lin SH, Wu HF, Chu MC, Lee CW, Lin IC, Chang CW, Liu YC, Chen TC, Lin YJ, Ian Shih YY, Chen YY.MR imaging central thalamic deep brain stimulation restored autistic-like social deficits in the rat. Brain Stimul. 2019 Nov - Dec;12(6):1410-1420.

6

Jeng JS, Li CT, Lin HC, Tsai SJ, Bai YM, Su TP, Chang YW, Cheng CM. Antidepressant-resistant depression is characterized by reduced short- and long-interval cortical inhibition. Psychological Medicine. 2019 Jun 3:1-7.

7

Lee CW, Chen YJ, Wu HF, Chung YJ, Lee YC, Li CT*, Lin HC*. Ketamine ameliorates severe traumatic event-induced antidepressant-resistant depression in a rat model through ERK activation. Prog Neuropsychopharmacol Biol Psychiatry. 2019 Mar ;93:102-113.

8

Wu HF, Chen YJ, Chu MC, Hsu YT, Lu TY, Chen IT, Chen PS, Lin HC*. Deep Brain Stimulation Modified Autism-like Deficits via the Serotonin System in a Valproic Acid-Induced Rat Model. International Journal of Molecular Sciences. 2018 Sep; 19(9) pii: E2840.

9

Kuo CJ, Huang CC, Chou SY, Lo YC, Kao TJ, Huang NK, Lin C, Lin HC, Lin HC*, Lee YC*. Potential therapeutic effect of curcumin, a natural mTOR inhibitor, in tuberous sclerosis complex. Phytomedicine. 2019 Feb;54:132-139. *co-corresponding authors.

10

Lee YC, Huang WC, Lin JH, Kao TJ, Lin HC, Lee KH, Lin HC, Shen CJ, Chang WC, Huang CC. Znf179 E3 ligase-mediated TDP-43 polyubiquitination is involved in TDP-43- ubiquitinated inclusions (UBI) (+)-related neurodegenerative pathology. Journal of Biomedical Science. 2018 Nov 8;25(1):76.

11

Lee HT, Lee KI, Lin HC, Lee TS. Genetic Deletion of Soluble Epoxide Hydroxylase Causes Anxiety-Like Behaviors in Mice. 2018 Jul Molecular Neurobiology.doi: 10.1007/s12035-018-1261-z.

12

Wu HF, Chen PS, Hsu YT, Lee CW, Wang TF, Chen YJ, Lin HC. D-Cycloserine ameliorates autism-like deficits by removing GluA2-containing AMPA receptors in a valproic acid-induced rat model. Molecular Neurobiology. 2018 Jun;55(6):4811-4824.

13

Chang LH, Lin HC, Huang SS, Chen IC, Chu KW, Chih CL, Liang YW, Lee YC, Chen YY, Lee YH, Lee IH. Blockade of soluble epoxide hydrolase attenuates post-ischemic neuronal hyperexcitation and confers resilience against stroke with TrkB activation. Scientific Reports . 2018 Jan 8;8(1):118.

14

Yeh CH, Hsieh LP, Lin MC, Wei TS, Lin HC, Chang CC, Hsing CH. Dexmedetomidine reduces lipopolysaccharide induced neuroinflammation, sickness behavior, and anhedonia. PLoS One 2018, Jan;13 (1):e0191070.

15

Wu HF, Chen PS, Chen YJ, Lee CW, Chen IT, Lin HC*. Alleviation of N-methyl-D-aspartate Receptor-Dependent Long-term depression via regulation of the Glycogen Synthase Kinase-3β pathway in the amygdala of a valproic acid-induced animal model of autism. Molecular Neurobiology 2017 Sep; 54(7), 5264-5276.

16

Wu HF#, Chen YJ#, Wu SZ, Lee CW, Chen IT, Lee YC, Huang CC, Hsing CH, Tang CW, Lin HC*. Soluble epoxide hydrolase inhibitor and 14, 15-epoxyeicosatrienoic acid-facilitated long-term potentiation through cAMP and CaMKII in the hippocampus. Neural Plasticity. 2017 Jul. #equal contribution.

17

Huang HJ, Wang YT, Lin HC, Lee YH, Lin AM. Soluble Epoxide Hydrolase Inhibition Attenuates MPTP-Induced Neurotoxicity in the Nigrostriatal Dopaminergic System: Involvement of α-Synuclein Aggregation and ER Stress. Molecular Neurobiology. 2017Aug. DOI: 10.1007/s12035-017-0726-9.

18

Wang CF, Yang SH, Lin SH, Chen PC, Lo YC, Pan HC, Lai HY, Liao LD, Lin HC, Chen HY, Huang WC, Huang WJ, Chen YY. A proof-of-principle simulation for closed-loop control based on preexisting experimental thalamic DBS-enhanced instrumental learning. Brain Stimulation 2017 Feb. pii: S1935-861X(17) 30611-3.

19

Lee KI, Lin HC, Lee HT, Tsai FC, Lee TS. Loss of transient receptor potential ankyrin 1 channel deregulates emotional, social, cognitive, learning and memory development. Molecular Neurobiology 2017 Jul;54(5):3606-3617.

20

Wang YT, Lin HC, Zhao WZ, Huang HJ, Lo YL, Wang HT, Lin AM. Acrolein acts as a neurotoxin in the nigrostriatal dopaminergic system of rat: involvement of α-synuclein aggregation and programmed cell death. Scientific Reports . 2017 Apr 12;7:45741.

21

Tsou JH, Yang YC, Pao PC, Lin HC, Huang NK, Lin ST, Hsu KS, Yeh CM, Lee KH, Kuo CJ, Yang DM, Lin JH, Chang WC, Lee YC. Important roles of Ring Finger Protein 112 in embryonic vascular development and brain function. Molecular Neurobiology. 2017 Apr;54(3):2286-2300.

22

Li CT, Lu CF, Lin HC, Huang YZ, Juan CH, Su TP, Bai YM, Chen MH, Lin WC. Cortical inhibitory and excitatory function in drug-naive generalized anxiety disorder. Brain Stimulation 2016 Dec. pii: S1935-861X(16) 30389-8.

23

Yang SH, Chen YY, Lin SH, Liao LD, Lu HS, Wang CF, Chen PC, Lo YC, Phan TD, Chao HY, Lin HC, Lai HY, Huang WC. A sliced inverse regression (SIR) decoding the forelimb movement from neuronal spikes in the rat motor cortex. Frontiers in Neuroscience.2016 Nov. doi: 10.3389/fnins.2016.00556

24

Chang CF, Lee YH, Lee KH, Lin HC, Chen CL, Shen CK, Huang CC. Therapeutic effect of berberine on TDP-43-related pathogenesis in FTLD and ALS. Journal of Biomedical Science 2016 Oct; 23:72.

25

Lee KI, Lee HT, Lin HC, Tasy HJ, Tsai FC, Shyue SK, Lee TS. Role of transient receptor potential Ankyrin 1 channels in Alzheimer’s disease. Journal of Neuroinflammation 2016 Apr; 13(1): 92. doi: 10.1186/s12974-016-0557-z.

26

Lee KI, Chiang CW, Lin HC, Zhao JF, Li CT, Shyue SK, Lee TS. Maternal exposure to di-(2-ethylhexyl) phthalate exposure deregulates blood pressure, adiposity, cholesterol metabolism and social interaction in mouse offspring. Archives of Toxicology 2016 May; 90(5): 1211-1224.

27

Lin HC#Pan HC#, Lin SH, Lo YC, Shen Elise TH, Liao LD, Liao PH, Chien YW, Liao KD, Jaw FS, Chu KW, Lai HY, Chen YY. Central thalamic deep-brain stimulation alters striatal–thalamic connectivity in cognitive neural behavior. #equal contribution. Frontiers in Neural Circuits 2016 Jan 13; 9:87. doi: 10.3389/fncir.2015.00087.  #equal contribution.

28

Wu HF, Yen HJ, Huang CC, Lee YC,Wu SZ , Lee TS, Lin HC*, Soluble epoxide hydrolase inhibitor enhances synaptic neurotransmission and plasticity in mouse prefrontal cortex. Journal of Biomedical Science 2015 Oct; 22:94. doi: 10.1186/s12929-015-0202-7. SCI.

29

Lin HC# Li CT#, David Tan TW, Cheng CW, Chou TK, Kong FL, Yu TH, Huang WS, Su DP, Liu RS, Skye Yeh HH. Non-linear alteration of serotonin transport availability in posttraumatic stress disorder measured with 4- [18F]ADAM positron emission tomography. Current Molecular Imaging  2015; 4: 57-64.  #equal contribution.

30

Wang CY, Lin HC#, Song YP#, Hsu YT#, Lin SY, Hsu PC, Lin CH, Hung CC, Hsu MC, Kuo YM, Lee YJ, Hsu CY, Lee YH. 2015. Protein kinase C dependent growth-associated protein 43 phosphorylation regulates gephyrin aggregation at developing GABAergic synapses. Molecular and Cellular Biology  2015 May; 35(10):1712-1726. #equal contribution.

31

Chen YW, Lin HC,Ng MC, Hsiao YH, Wang CC, Gean PW, Chen PS. Activation of mGluR2/3 underlies the effects of N-acetylcystein on amygdala associated autism-like phenotypes in a valproate-induced rat model of autism. Frontiers in Behavioral Neuroscience. 2014 Jun; 8: 219

32

Wang CC#, Lin HC#Chan YH, Gean PW, Yang YK, Chen PS. (2013). 5-HT1A-receptor agonist modified amygdala activity and amygdala-associated social behavior in a valproate-induced rat autism model. International Journal of Neuropsychopharmacology 2013 Oct; 16(9):2027-2039.  # equal contribution.

33

Lin HC, Gean PW, Wang CC, Chan YH, Chen PS. The Amygdala Excitatory/Inhibitory Balance in a Valproate-induced Rat Autism Model. PLoS One 2013, Jan; 8(1):e55248.

34

Lin HC, Tseng YC, Mao S, Gean PW. GABAA receptor endocytosis in the basolateral amygdala is critical to the reinstatement of fear memory measured with fear-potentiated startle. The Journal of Neuroscience 2011 Tun; 31(24):8851-8861.

35

Lin HC, Mao SC, Su CL, Gean PW. Alterations of excitatory transmission in the lateral amygdala during expression and extinction of fear memory. International Journal of Neuropsychopharmacology 2010 Apr; 13(3):335-345.

36

Lin HC, Mao SC, Su CL, Gean PW. The role of prefrontal cortex CB1 receptors in the modulation of fear memory.  Cereb Cortex 2009 Jan;19(1):165-175.

37

Lin HC, Mao SC, Gean PW. Block of GABAA receptor insertion in the amygdala impairs extinction of conditioned fear. Biological Psychiatry 2009 Oct; 66(7) 665-673.

38

Mao SC, Lin HC, Gean PW. Augmentation of fear extinction by infusion of glycine transporter blockers into the amygdala. Molecular Pharmacology 2009 Aug; 76(2):369-378. 

39

Lin HC, Mao SC, Chen PS, Gean PW. Chronic cannabinoid administration in vivo compromises extinction of fear memory. Learning & Memory 2008 Dec; 15(12):876-884.

40

Mao SC, Lin HC, Gean PW. Augmentation of Fear Extinction by D-Cycloserine is Blocked by Proteasome Inhibitors. Neuropsychopharmacology 2008 Dec; 33(13):3085-3095.

41

Lin HC, Mao SC, and Gean PW. Effects of intra-amygdala infusion of CB1 receptor agonists on the reconsolidation of fear-potentiated startle. Learning & Memory 2006 May; 13(3): 316-321.

42

Yeh SH, Mao SC,Lin HC, Gean PW. Synaptic expression of glutamate receptor after encoding of fear memory in the rat amygdala. Molecular Pharmacology 2006 Jan; 69(1): 299-308.

43

Lin HC, Wang SJ, Luo MZ, Gean PW. Activation of group II metabotropic glutamate receptors induces long-term depression of synaptic transmission in the rat amygdala. The Journal of Neuroscience. 2000 Dec; 20(24): 9017–9024.

排序編號 年度 計畫名稱 單位 計畫期間
1 類長期增益之突觸塑性作為難治型憂鬱症動物模式之治療指標:非侵入性之重覆透顱磁刺激與抑制可溶環氧化物水解酶 科技部-優秀年輕學者研究計畫
2 壓力誘發動物情緒失調之突觸機制:藥物和電刺激治療 科技部-傑出學者養成計畫
職稱/學位 姓名
研究助理 吉翔、鍾岳融
博士生 李旂緯、劉沛勳、初銘家
碩士生 謝宗翰、高珮瑜、蔡思綺、廖永維、張傑宥、張景翔、王方庭
實驗室畢業生(大學部) 陳怡婷、楊巧慈、宋瑋倫
實驗室畢業生(博士班) 吳函芳
實驗室畢業生(碩士班) 翁崇瀚、許雅婷、吳函芳、顏欣如、朱凱文、陳怡如、李旂緯、陳翊端、呂亭儀、鍾岳融、張芸綺

1.自閉症是一種神經發育性的疾病,主要病徵為社交能力障礙與溝通能力的缺乏,且常出現反覆行為與過度焦慮反應。因此運用表現類似自閉症行為之齧齒類動物模型來探討自閉症相關大腦異常是一種具挑戰性但可能成果豐碩的方法。我們研究主要探討自閉症動物其大腦神經細胞突觸興奮性和抑制性間平衡改變的機制,並尋找藥物改善自閉症所導致之神經與行為異常。

2.現今因社經環境壓力導致人類精神疾患人口日益增多。我們研究主題著重於探討精神疾患所引起大腦功能改變的因素,並尋找調控情緒反應的關鍵蛋白。研究策略結合神經藥物、分子生物學、動物行為模式和神經電生理技術剖析精神創傷或生理性腦血管疾病造成憂鬱,焦慮情緒障礙表現的神經生理機制。

 

3. 利用非藥物治療像腦部深層電刺激方式,改善神經發育性疾病或精神相關疾病,並探討其神經迴路之作用機制,其優點為減少藥物治療的使用劑量以及使用頻率,更可降低藥物所導致的副作用,開發臨床上除藥物使用之外的嶄新治療策略。